- HIGH
- Research
- Tier 1
- Peer-Reviewed Research
Neutrophil extracellular traps contribute to peri-implant bone loss
- Source
- Journal of Clinical Periodontology
- Author
- Ying Li, Chenglin Yang, Xiaojing Li, Wenping Zhang, Dashan Wang, Yixiao Xing, Youcheng Yu, Baodong Zhao, Fan Li
- Originally at
- onlinelibrary.wiley.com(opens in a new tab)
Summary and scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol. Not the original publisher.
Why it matters for dental
This study identifies a neutrophil extracellular trap (NET) pathway that drives peri-implant bone loss and shows that targeting the MIF–CD74–p38 MAPK signaling between macrophages and neutrophils can reduce that loss.
Key points
- 01
Researchers found increased NET-associated markers in peri-implantitis specimens that correlated with inflammatory cytokines.
- 02
Local DNase I treatment in a rat peri-implantitis model attenuated peri-implant bone resorption and inflammation.
- 03
Single-cell and spatial transcriptomics identified a NETosis-associated neutrophil subpopulation (NNeu) and pro-inflammatory macrophages (PMac) as the candidate upstream population.
- 04
PMac-derived MIF promoted NETosis via CD74–p38 MAPK signalling in vitro; experimental modulation of MIF–CD74 signalling in vivo altered NET formation, inflammation, and peri-implant bone loss.
Who should care
- Specialist
- Academia / research
Read the original
Journal of Clinical Periodontology
Full reporting and any paywalled content live on onlinelibrary.wiley.com. We summarize and score; we do not republish.